General Information of the Compound
Compound ID
CP0904273
Compound Name
1-(4-Fluoro benzenesulfonyl)-5-methoxy-3-(4-methyl-[1,4]diazepane-1-yl methyl)-1H-indole Dihydrochloride
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Structure
Formula
C22H28Cl2FN3O3S
Molecular Weight
504.455
Canonical SMILES
COc1ccc2c(c1)c(CN1CCCN(C)CC1)cn2S(=O)(=O)c1ccc(F)cc1.Cl.Cl
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InChI
InChI=1S/C22H26FN3O3S.2ClH/c1-24-10-3-11-25(13-12-24)15-17-16-26(22-9-6-19(29-2)14-21(17)22)30(27,28)20-7-4-18(23)5-8-20;;/h4-9,14,16H,3,10-13,15H2,1-2H3;2*1H
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InChIKey
RVPZQMWECHCQPK-UHFFFAOYSA-N
Physicochemical Property
logP
4.0071
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
54.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137645373
ChEMBL ID
CHEMBL4083893
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 7.79 nM
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