General Information of the Compound
Compound ID
CP0893856
Compound Name
1-(2,2-difluoro-1,3-benzodioxol-5-yl)-N-{(2R)-2-[3-(hydroxymethyl)phenyl]-3,4-dihydro-2H-chromen-4-yl}cyclopropanecarboxamide
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Structure
Formula
C27H23F2NO5
Molecular Weight
479.479
Canonical SMILES
O=C(NC1C[C@H](c2cccc(CO)c2)Oc2ccccc21)C1(c2ccc3c(c2)OC(F)(F)O3)CC1
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InChI
InChI=1S/C27H23F2NO5/c28-27(29)34-22-9-8-18(13-24(22)35-27)26(10-11-26)25(32)30-20-14-23(17-5-3-4-16(12-17)15-31)33-21-7-2-1-6-19(20)21/h1-9,12-13,20,23,31H,10-11,14-15H2,(H,30,32)/t20?,23-/m1/s1
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InChIKey
DGNDJPPKJOAWAC-GWQXNCQPSA-N
Physicochemical Property
logP
4.9133
Rotatable Bonds
5
Heavy Atom Count
35
Polar Areas
77.02
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
35

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 121301194
ChEMBL ID
CHEMBL4094248
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02042, Cystic fibrosis transmembrane conductance regulator
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000535 CFBE41o- Homo sapiens (Human)  1
1
EC50 = 1600 nM
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