General Information of the Compound
Compound ID
CP0892602
Compound Name
(1-{3-(3-Chloro-phenyl)-4-[(R)-4-(1H-indol-3-ylmethyl)-2,5-dioxo-imidazolidin-1-yl]-3-methyl-butyl}-piperidin-4-yl)-ethyl-carbamic acid benzyl ester
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Structure
Formula
C38H44ClN5O4
Molecular Weight
670.254
Canonical SMILES
CCN(C(=O)OCc1ccccc1)C1CCN(CCC(C)(CN2C(=O)N[C@H](Cc3c[nH]c4ccccc34)C2=O)c2cccc(Cl)c2)CC1
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InChI
InChI=1S/C38H44ClN5O4/c1-3-43(37(47)48-25-27-10-5-4-6-11-27)31-16-19-42(20-17-31)21-18-38(2,29-12-9-13-30(39)23-29)26-44-35(45)34(41-36(44)46)22-28-24-40-33-15-8-7-14-32(28)33/h4-15,23-24,31,34,40H,3,16-22,25-26H2,1-2H3,(H,41,46)/t34-,38?/m1/s1
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InChIKey
YQCQEQGDXWNQQT-ZCJFERALSA-N
Physicochemical Property
logP
6.7553
Rotatable Bonds
12
Heavy Atom Count
48
Polar Areas
97.98
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
48

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 489340
ChEMBL ID
CHEMBL319233
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 77 nM
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