General Information of the Compound
Compound ID
CP0890907
Compound Name
4-[4-({(3R)-3-[(R)-Cyclohexyl(hydroxy)methyl]-1-ethyl-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]-N-methylbenzamidehydrochloride
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Structure
Formula
C32H43ClN4O5
Molecular Weight
599.172
Canonical SMILES
CCN1C(=O)[C@@H]([C@H](O)C2CCCCC2)NC(=O)C12CCN(Cc1ccc(Oc3ccc(C(=O)NC)cc3)cc1)CC2.Cl
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InChI
InChI=1S/C32H42N4O5.ClH/c1-3-36-30(39)27(28(37)23-7-5-4-6-8-23)34-31(40)32(36)17-19-35(20-18-32)21-22-9-13-25(14-10-22)41-26-15-11-24(12-16-26)29(38)33-2;/h9-16,23,27-28,37H,3-8,17-21H2,1-2H3,(H,33,38)(H,34,40);1H/t27-,28-;/m1./s1
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InChIKey
JEHLDWLKIRQMSR-LTRMXRMOSA-N
Physicochemical Property
logP
3.883
Rotatable Bonds
8
Heavy Atom Count
42
Polar Areas
111.21
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
6
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56661525
ChEMBL ID
CHEMBL1813447
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 20000 nM
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