General Information of the Compound
Compound ID
CP0887833
Compound Name
(E)-3-[6-Amino-9-((3S,4R,5R)-3,4-dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-9H-purin-8-yl]-1-phenyl-propenone
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Structure
Formula
C19H19N5O5
Molecular Weight
397.391
Canonical SMILES
Nc1ncnc2c1nc(/C=C/C(=O)c1ccccc1)n2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O
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InChI
InChI=1S/C19H19N5O5/c20-17-14-18(22-9-21-17)24(19-16(28)15(27)12(8-25)29-19)13(23-14)7-6-11(26)10-4-2-1-3-5-10/h1-7,9,12,15-16,19,25,27-28H,8H2,(H2,20,21,22)/b7-6+/t12-,15-,16-,19-/m1/s1
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InChIKey
VRKBZQOPVJHRLW-VFIQZALSSA-N
Physicochemical Property
logP
-0.0839
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
156.61
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
10
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10250190
SID: 15253451
ChEMBL ID
CHEMBL3350496
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 46600 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
EC50 > 100000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 9830 nM
   TI
   LI
   LO
   TS