General Information of the Compound
Compound ID
CP0887522
Compound Name
rac-7-(cyclohexanecarbonyl)-2-((1S,2R)-2-phenylcyclopropyl)tetrahydroimidazo[1,5-a]pyrazine-1,3(2H,5H)-dione
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Structure
Formula
C22H27N3O3
Molecular Weight
381.476
Canonical SMILES
O=C(C1CCCCC1)N1CCN2C(=O)N([C@H]3C[C@@H]3c3ccccc3)C(=O)C2C1
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InChI
InChI=1S/C22H27N3O3/c26-20(16-9-5-2-6-10-16)23-11-12-24-19(14-23)21(27)25(22(24)28)18-13-17(18)15-7-3-1-4-8-15/h1,3-4,7-8,16-19H,2,5-6,9-14H2/t17-,18+,19?/m1/s1
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InChIKey
IRMLAZVFEBKCLD-YTYFACEESA-N
Physicochemical Property
logP
2.5978
Rotatable Bonds
3
Heavy Atom Count
28
Polar Areas
60.93
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
3
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56680145
ChEMBL ID
CHEMBL1808158
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT04361, Protein smoothened
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000109 COS-1 Chlorocebus aethiops (Green monkey)  1
1
IC50 > 1500 nM
   TI
   LI
   LO
   TS