General Information of the Compound
Compound ID
CP0878574
Compound Name
(4-(N-(3-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)propyl)acetamido)benzoyl)-L-glutamic acid
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Structure
Formula
C23H26N6O7
Molecular Weight
498.496
Canonical SMILES
CC(=O)N(CCCc1cc2c(=O)[nH]c(N)nc2[nH]1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1
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InChI
InChI=1S/C23H26N6O7/c1-12(30)29(10-2-3-14-11-16-19(25-14)27-23(24)28-21(16)34)15-6-4-13(5-7-15)20(33)26-17(22(35)36)8-9-18(31)32/h4-7,11,17H,2-3,8-10H2,1H3,(H,26,33)(H,31,32)(H,35,36)(H4,24,25,27,28,34)/t17-/m0/s1
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InChIKey
DMNZBKJKYWYHAB-KRWDZBQOSA-N
Physicochemical Property
logP
0.8669
Rotatable Bonds
11
Heavy Atom Count
36
Polar Areas
211.57
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
7
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 156016594
ChEMBL ID
CHEMBL4642637
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01873, Trifunctional purine biosynthetic protein adenosine-3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000220 KB Homo sapiens (Human)  2
1
IC50 = 40.11 nM
   TI
   LI
   LO
   TS
2
IC50 > 1000 nM
   TI
   LI
   LO
   TS