General Information of the Compound
Compound ID
CP0877269
Compound Name
2-(5-((2-amino-4-cyclopropylpyrimidin-5-yl)methoxy)-2-bromo-4-hydroxybenzylidene)thieno[2,3-b]pyridin-3(2H)-one
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Structure
Formula
C22H17BrN4O3S
Molecular Weight
497.374
Canonical SMILES
Nc1ncc(COc2cc(/C=C3\Sc4ncccc4C3=O)c(Br)cc2O)c(C2CC2)n1
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InChI
InChI=1S/C22H17BrN4O3S/c23-15-8-16(28)17(30-10-13-9-26-22(24)27-19(13)11-3-4-11)6-12(15)7-18-20(29)14-2-1-5-25-21(14)31-18/h1-2,5-9,11,28H,3-4,10H2,(H2,24,26,27)/b18-7-
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InChIKey
RTDUHCBEYYZOCY-WSVATBPTSA-N
Physicochemical Property
logP
4.7078
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
111.22
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 140897160
ChEMBL ID
CHEMBL4531201
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT05581, Cyclic GMP-AMP synthase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000040 THP-1 Homo sapiens (Human)  1
1
IC50 = 2500 nM
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