General Information of the Compound
Compound ID
CP0875165
Compound Name
N1,N19-bis(2-(2-(2-(2-(4-(3-(6-chloro-2-guanidinoquinazolin-4-yl)phenyl)piperazin-1-yl)ethoxy)ethoxy)ethoxy)ethyl)-4,7,10,13,16-pentaoxanonadecane-1,19-diamide
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Structure
Formula
C68H96Cl2N16O13
Molecular Weight
1416.521
Canonical SMILES
N=C(N)Nc1nc(-c2cccc(N3CCN(CCOCCOCCOCCNC(=O)CCOCCOCCOCCOCCOCCC(=O)NCCOCCOCCOCCN4CCN(c5cccc(-c6nc(NC(=N)N)nc7ccc(Cl)cc67)c5)CC4)CC3)c2)c2cc(Cl)ccc2n1
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InChI
InChI=1S/C68H96Cl2N16O13/c69-53-7-9-59-57(49-53)63(79-67(77-59)81-65(71)72)51-3-1-5-55(47-51)85-19-15-83(16-20-85)23-29-93-35-41-97-39-33-91-27-13-75-61(87)11-25-89-31-37-95-43-45-99-46-44-96-38-32-90-26-12-62(88)76-14-28-92-34-40-98-42-36-94-30-24-84-17-21-86(22-18-84)56-6-2-4-52(48-56)64-58-50-54(70)8-10-60(58)78-68(80-64)82-66(73)74/h1-10,47-50H,11-46H2,(H,75,87)(H,76,88)(H4,71,72,77,79,81)(H4,73,74,78,80,82)
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InChIKey
XSXGLPWIFIVMPW-UHFFFAOYSA-N
Physicochemical Property
logP
4.96394
Rotatable Bonds
48
Heavy Atom Count
99
Polar Areas
348.05
Hydrogen Bond Donor Count
8
Hydrogen Bond Acceptor Count
23
Complexity
99

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 134147709
ChEMBL ID
CHEMBL3950900
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03762, Sodium/hydrogen exchanger 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000422 OK Didelphis virginiana (North American opossum)  1
1
IC50 = 2.818 nM
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Protein ID: PT04309, Sodium/hydrogen exchanger 3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000422 OK Didelphis virginiana (North American opossum)  1
1
IC50 = 134.9 nM
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