General Information of the Compound
Compound ID
CP0872714
Compound Name
Hexobarbital
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Synonyms
(+-)-Hexobarbital
1,5-Dimethyl-5-(1-cyclohexenyl)barbituric acid
2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-cyclohexen-1-yl)-1,5-dimethyl
5-(1-CYCLOHEXEN-1-YL)-1,5-DIMETHYLBARBITURIC ACID
5-(1-Cyclohexen-1-yl)-1,5-dimethyl-2,4,6(1H,3H,5H)-pyrimidinetrione
5-(1-Cyclohexenyl)-1,5-dimethylbarbituric acid
5-(1-Cyclohexenyl-1)-1-methyl-5-methylbarbituric acid
5-(cyclohex-1-en-1-yl)-1,5-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
5-(cyclohexen-1-yl)-1,5-dimethyl-1,3-diazinane-2,4,6-trione
5-(delta-1,2-Cyclohexenyl)-5-methyl-N-methyl-barbitursaeure [German]
5-(delta-1,2-cyclohexenyl)-5-methyl-N-methyl-barbitursaeure
5-(delta.-1,2-cyclohexenyl)-5-methyl-N-methyl-barbitursaeure
5-cyclohex-1-en-1-yl-1,5-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione
5-cyclohex-1-en-1-yl-2-hydroxy-1,5-dimethylpyrimidine-4,6(1H,5H)-dione
Barbidorm
Citodon
Citopan
Citopan (TN)
Cyclonal
Cyclopan
Dorico
Enhexymal
Enhexymalum
Esobarbitale
Esobarbitale [DCIT]
Esobarbitale [Italian]
Evipal
Evipan
Evipan (TN)
Hexabarbital;Hexobarbitalum
Hexanastab oral
Hexenal (barbiturate)
Hexobarbital
Hexobarbital (JAN/INN)
Hexobarbital (VAN)
Hexobarbital [INN:JAN]
Hexobarbitalum [INN-Latin]
Hexobarbitone
Hexobarbitonum
Methexenyl
Methylhexabarbital
Methylhexabital
N-Methyl-5-cyclohexenyl-5-methylbarbituric acid
Narcosan
Noctivane
Sodium hexobarbital
Sombucaps
Sombulex
Somnalert
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Structure
Formula
C12H16N2O3
Molecular Weight
236.271
Canonical SMILES
CN1C(=O)NC(=O)C(C)(C2=CCCCC2)C1=O
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InChI
InChI=1S/C12H16N2O3/c1-12(8-6-4-3-5-7-8)9(15)13-11(17)14(2)10(12)16/h6H,3-5,7H2,1-2H3,(H,13,15,17)
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InChIKey
UYXAWHWODHRRMR-UHFFFAOYSA-N
CAS
56-29-1
Physicochemical Property
logP
1.2013
Rotatable Bonds
1
Heavy Atom Count
17
Polar Areas
66.48
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
3
Complexity
17

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 3608
SID: 15415683
ChEMBL ID
CHEMBL7728
DrugBank ID
DB01355
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06109, Geminin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000015 SW480 Homo sapiens (Human)  1
1
Potency ~ 580.5 nM
   TI
   LI
   LO
   TS
Clinical Information about the Compound
Drug 1 ( Hexobarbital )
Drug Name Hexobarbital
Indication
Anaesthesia
Approved
Target(s)
GABA(A) receptor alpha-1 (GABRA1)
Antagonist