General Information of the Compound
Compound ID
CP0862732
Compound Name
1-((2R,3R,4S,5R,6R)-4-Benzyloxy-3,5-dihydroxy-6-hydroxymethyl-tetrahydro-pyran-2-yl)-3-[3-((4R,5R)-3,3-dibutyl-7-dimethylamino-4-hydroxy-1,1-dioxo-2,3,4,5-tetrahydro-1H-1lambda(6)-benzo[b]thiepin-5-yl)-phenyl]-urea
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Structure
Formula
C40H55N3O9S
Molecular Weight
753.959
Canonical SMILES
CCCCC1(CCCC)CS(=O)(=O)c2ccc(N(C)C)cc2[C@@H](c2cccc(NC(=O)N[C@@H]3O[C@H](CO)[C@@H](O)[C@H](OCc4ccccc4)[C@H]3O)c2)[C@H]1O
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InChI
InChI=1S/C40H55N3O9S/c1-5-7-19-40(20-8-6-2)25-53(49,50)32-18-17-29(43(3)4)22-30(32)33(37(40)47)27-15-12-16-28(21-27)41-39(48)42-38-35(46)36(34(45)31(23-44)52-38)51-24-26-13-10-9-11-14-26/h9-18,21-22,31,33-38,44-47H,5-8,19-20,23-25H2,1-4H3,(H2,41,42,48)/t31-,33-,34-,35-,36+,37-,38-/m1/s1
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InChIKey
NAVXGANAZYCKRD-HANJNXQLSA-N
Physicochemical Property
logP
4.5454
Rotatable Bonds
14
Heavy Atom Count
53
Polar Areas
177.89
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
10
Complexity
53

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 24987685
SID: 56329691
ChEMBL ID
CHEMBL3897389
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03505, Ileal sodium/bile acid cotransporter
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 6.9 nM
   TI
   LI
   LO
   TS