General Information of the Compound
Compound ID
CP0862330
Compound Name
(2-amino-1-(4-fluorophenyl)-1H-imidazol-5-yl)(2-(4-chlorophenylamino)-4-methylthiazol-5-yl)methanone
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Structure
Formula
C20H15ClFN5OS
Molecular Weight
427.892
Canonical SMILES
Cc1nc(Nc2ccc(Cl)cc2)sc1C(=O)c1cnc(N)n1-c1ccc(F)cc1
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InChI
InChI=1S/C20H15ClFN5OS/c1-11-18(29-20(25-11)26-14-6-2-12(21)3-7-14)17(28)16-10-24-19(23)27(16)15-8-4-13(22)5-9-15/h2-10H,1H3,(H2,23,24)(H,25,26)
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InChIKey
PIZWNHKSSVITKB-UHFFFAOYSA-N
Physicochemical Property
logP
4.98652
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
85.83
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
7
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145990511
ChEMBL ID
CHEMBL4288432
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00840, Adenosine receptor A1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 19800 nM
   TI
   LI
   LO
   TS
Protein ID: PT00862, Adenosine receptor A2a
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 13000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01278, Adenosine receptor A2b
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki > 10000 nM
   TI
   LI
   LO
   TS
Protein ID: PT01279, Adenosine receptor A3
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 871 nM
   TI
   LI
   LO
   TS