General Information of the Compound
Compound ID
CP0860732
Compound Name
1-[(4-Fluorophenyl)sulfonyl]-5-methoxy-3-[(1-piperazinyl)methyl]-1H-indole Dimesylate
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Structure
Formula
C22H30FN3O9S3
Molecular Weight
595.693
Canonical SMILES
COc1ccc2c(c1)c(CN1CCNCC1)cn2S(=O)(=O)c1ccc(F)cc1.CS(=O)(=O)O.CS(=O)(=O)O
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InChI
InChI=1S/C20H22FN3O3S.2CH4O3S/c1-27-17-4-7-20-19(12-17)15(13-23-10-8-22-9-11-23)14-24(20)28(25,26)18-5-2-16(21)3-6-18;2*1-5(2,3)4/h2-7,12,14,22H,8-11,13H2,1H3;2*1H3,(H,2,3,4)
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InChIKey
JRSOATLLRULBNU-UHFFFAOYSA-N
Physicochemical Property
logP
1.4392
Rotatable Bonds
5
Heavy Atom Count
38
Polar Areas
172.31
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
10
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137641062
ChEMBL ID
CHEMBL4073450
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 6.9 nM
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