General Information of the Compound
Compound ID
CP0859834
Compound Name
N-(4-chloro-2-(pyridine-4-carbonyl)phenyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide
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Structure
Formula
C21H18ClN3O3S
Molecular Weight
427.913
Canonical SMILES
O=C(c1ccncc1)c1cc(Cl)ccc1NS(=O)(=O)c1ccc2c(c1)CNCC2
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InChI
InChI=1S/C21H18ClN3O3S/c22-17-2-4-20(19(12-17)21(26)15-6-8-23-9-7-15)25-29(27,28)18-3-1-14-5-10-24-13-16(14)11-18/h1-4,6-9,11-12,24-25H,5,10,13H2
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InChIKey
ZFACXJFGUZPDGM-UHFFFAOYSA-N
Physicochemical Property
logP
3.4125
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
88.16
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10410294
SID: 15427865
ChEMBL ID
CHEMBL3716905
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03549, C-C chemokine receptor type 9
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000116 MOLT-4 Homo sapiens (Human)  2
1
IC50 = 100 nM
   TI
   LI
   LO
   TS
2
IC50 < 1000 nM
   TI
   LI
   LO
   TS