General Information of the Compound
Compound ID
CP0854700
Compound Name
1-[(4-Isopropylphenyl)sulfonyl]-4-methoxy-3-[(4-methyl-1-piperazinyl)methyl]-1H-indole Dihydrochloride
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Structure
Formula
C24H33Cl2N3O3S
Molecular Weight
514.519
Canonical SMILES
COc1cccc2c1c(CN1CCN(C)CC1)cn2S(=O)(=O)c1ccc(C(C)C)cc1.Cl.Cl
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InChI
InChI=1S/C24H31N3O3S.2ClH/c1-18(2)19-8-10-21(11-9-19)31(28,29)27-17-20(16-26-14-12-25(3)13-15-26)24-22(27)6-5-7-23(24)30-4;;/h5-11,17-18H,12-16H2,1-4H3;2*1H
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InChIKey
LPRJLVXGSNPITB-UHFFFAOYSA-N
Physicochemical Property
logP
4.6013
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
54.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137647787
ChEMBL ID
CHEMBL4085003
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 11.6 nM
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