General Information of the Compound
Compound ID
CP0852468
Compound Name
tert-butyl 2-[[(3R,4S)-6-cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]amino]acetate
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Structure
Formula
C18H24N2O4
Molecular Weight
332.4
Canonical SMILES
CC(C)(C)OC(=O)CN[C@H]1c2cc(C#N)ccc2OC(C)(C)[C@@H]1O
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InChI
InChI=1S/C18H24N2O4/c1-17(2,3)24-14(21)10-20-15-12-8-11(9-19)6-7-13(12)23-18(4,5)16(15)22/h6-8,15-16,20,22H,10H2,1-5H3/t15-,16+/m0/s1
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InChIKey
RKAFAAAUJGBZPI-JKSUJKDBSA-N
Physicochemical Property
logP
2.06258
Rotatable Bonds
3
Heavy Atom Count
24
Polar Areas
91.58
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
24

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10592683
SID: 15621786
ChEMBL ID
CHEMBL57230
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL001024 MDR CCRF vcr1000 Homo sapiens (Human)  1
1
EC50 = 46773.51 nM
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