General Information of the Compound
Compound ID
CP0849538
Compound Name
(2R,3R)-5,7-Dimethoxy-2-(3,4,5-trimethoxyphenyl)chroman-3-yl 3-acetamido-4-fluorobenzoate
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Structure
Formula
C29H30FNO9
Molecular Weight
555.555
Canonical SMILES
COc1cc(OC)c2c(c1)O[C@H](c1cc(OC)c(OC)c(OC)c1)[C@H](OC(=O)c1ccc(F)c(NC(C)=O)c1)C2
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InChI
InChI=1S/C29H30FNO9/c1-15(32)31-21-9-16(7-8-20(21)30)29(33)40-26-14-19-22(35-3)12-18(34-2)13-23(19)39-27(26)17-10-24(36-4)28(38-6)25(11-17)37-5/h7-13,26-27H,14H2,1-6H3,(H,31,32)/t26-,27-/m1/s1
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InChIKey
OXZHUHGNLRNJCM-KAYWLYCHSA-N
Physicochemical Property
logP
4.7289
Rotatable Bonds
9
Heavy Atom Count
40
Polar Areas
110.78
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
40

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 71492589
SID: 163471924
ChEMBL ID
CHEMBL3582143
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01546, ATP-dependent translocase ABCB1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000350 MDA435/LCC6MDR1 Homo sapiens (Human)  1
1
IC50 = 14.8 nM
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Cell Viability or Cytotoxicity Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000309 NCTC clone 929 Mus musculus (Mouse)  1
1
IC50 > 100000 nM
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