General Information of the Compound
Compound ID
CP0849007
Compound Name
N-[4-Chloro-2-(6-methylpyridine-2-carbonyl)-phenyl]-4-(4-methyl-tetrahydropyran-4-yl)-benzenesulfonamide
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Structure
Formula
C25H25ClN2O4S
Molecular Weight
485.005
Canonical SMILES
Cc1cccc(C(=O)c2cc(Cl)ccc2NS(=O)(=O)c2ccc(C3(C)CCOCC3)cc2)n1
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InChI
InChI=1S/C25H25ClN2O4S/c1-17-4-3-5-23(27-17)24(29)21-16-19(26)8-11-22(21)28-33(30,31)20-9-6-18(7-10-20)25(2)12-14-32-15-13-25/h3-11,16,28H,12-15H2,1-2H3
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InChIKey
DEJQEPBWGLUZJS-UHFFFAOYSA-N
Physicochemical Property
logP
5.14332
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
85.36
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59788697
ChEMBL ID
CHEMBL3718996
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03549, C-C chemokine receptor type 9
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000116 MOLT-4 Homo sapiens (Human)  1
1
IC50 < 1000 nM
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