General Information of the Compound
Compound ID
CP0847443
Compound Name
1-(beta-D-2-Deoxyribofuranosyl)-4-hydroxyamino-5-hydroxymethylpyrimidin-2(1H)-one 5'-monophosphate
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Structure
Formula
C10H16N3O9P
Molecular Weight
353.224
Canonical SMILES
O=c1nc(NO)c(CO)cn1[C@H]1C[C@H](O)[C@@H](COP(=O)(O)O)O1
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InChI
InChI=1S/C10H16N3O9P/c14-3-5-2-13(10(16)11-9(5)12-17)8-1-6(15)7(22-8)4-21-23(18,19)20/h2,6-8,14-15,17H,1,3-4H2,(H,11,12,16)(H2,18,19,20)/t6-,7+,8+/m0/s1
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InChIKey
DJERGEPPASPBDG-XLPZGREQSA-N
Physicochemical Property
logP
-1.7056
Rotatable Bonds
6
Heavy Atom Count
23
Polar Areas
183.6
Hydrogen Bond Donor Count
6
Hydrogen Bond Acceptor Count
10
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 10570040
SID: 15598053
ChEMBL ID
CHEMBL1161224
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01883, Thymidylate synthase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000266 L1210 Mus musculus (Mouse)  2
1
Ki = 1910 nM
   TI
   LI
   LO
   TS
2
Ki = 2180 nM
   TI
   LI
   LO
   TS