General Information of the Compound
Compound ID
CP0846809
Compound Name
SID144199879
    Show/Hide
Structure
Formula
C34H37F3N4O4
Molecular Weight
622.688
Canonical SMILES
C[C@@H]1CN([C@H](C)CO)C(=O)c2c(c3ccccc3n2C)-c2ccccc2CO[C@H]1CN(C)C(=O)Nc1cccc(C(F)(F)F)c1
    Show/Hide
InChI
InChI=1S/C34H37F3N4O4/c1-21-17-41(22(2)19-42)32(43)31-30(27-14-7-8-15-28(27)40(31)4)26-13-6-5-10-23(26)20-45-29(21)18-39(3)33(44)38-25-12-9-11-24(16-25)34(35,36)37/h5-16,21-22,29,42H,17-20H2,1-4H3,(H,38,44)/t21-,22-,29+/m1/s1
    Show/Hide
InChIKey
TVRVECNDOYCBHZ-QLVXXPONSA-N
Physicochemical Property
logP
6.3859
Rotatable Bonds
5
Heavy Atom Count
45
Polar Areas
87.04
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
45

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 60193739
ChEMBL ID
CHEMBL2357556
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06124, Paired box protein Pax-8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000097 RMG-I Homo sapiens (Human)  1
1
AC50 = 5560 nM
   TI
   LI
   LO
   TS