General Information of the Compound
Compound ID
CP0846434
Compound Name
(E)-N-{4'-[(2-Methoxy-ethylamino)-methyl]-biphenyl-4-ylmethyl}-3-phenyl-N-pyridin-3-ylmethyl-acrylamide TFA
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Structure
Formula
C34H34F3N3O4
Molecular Weight
605.657
Canonical SMILES
COCCNCc1ccc(-c2ccc(CN(Cc3cccnc3)C(=O)/C=C/c3ccccc3)cc2)cc1.O=C(O)C(F)(F)F
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InChI
InChI=1S/C32H33N3O2.C2HF3O2/c1-37-21-20-34-22-27-9-14-30(15-10-27)31-16-11-28(12-17-31)24-35(25-29-8-5-19-33-23-29)32(36)18-13-26-6-3-2-4-7-26;3-2(4,5)1(6)7/h2-19,23,34H,20-22,24-25H2,1H3;(H,6,7)/b18-13+;
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InChIKey
ALEUPTXXLPRFBT-PUBYZPQMSA-N
Physicochemical Property
logP
6.3601
Rotatable Bonds
12
Heavy Atom Count
44
Polar Areas
91.76
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
5
Complexity
44

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 44397428
ChEMBL ID
CHEMBL186450
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01513, 5-hydroxytryptamine receptor 5A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
Ki = 6309.57 nM
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   LI
   LO
   TS