General Information of the Compound
Compound ID
CP0765778
Compound Name
3-((1H-Imidazol-1-yl)methyl)-N-((2S,3S)-3-methyl-1-oxo-1-(thiazol-2-ylamino)pentan-2-yl)benzamide
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Structure
Formula
C20H23N5O2S
Molecular Weight
397.504
Canonical SMILES
CC[C@H](C)[C@H](NC(=O)c1cccc(Cn2ccnc2)c1)C(=O)Nc1nccs1
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InChI
InChI=1S/C20H23N5O2S/c1-3-14(2)17(19(27)24-20-22-8-10-28-20)23-18(26)16-6-4-5-15(11-16)12-25-9-7-21-13-25/h4-11,13-14,17H,3,12H2,1-2H3,(H,23,26)(H,22,24,27)/t14-,17-/m0/s1
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InChIKey
MILCULQRTIGDJF-YOEHRIQHSA-N
Physicochemical Property
logP
3.1711
Rotatable Bonds
8
Heavy Atom Count
28
Polar Areas
88.91
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 73213175
ChEMBL ID
CHEMBL3105391
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01553, Type-2 angiotensin II receptor
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 42000 nM
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