General Information of the Compound
Compound ID
CP0704450
Compound Name
2-{[-6-methoxy-7-(2-methoxyethoxy)quinazolin-4-yl]amino}-5-(5-methyl-2-oxo-1,3-oxazolidin-3-yl)benzo-1,4-quinone
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Structure
Formula
C22H22N4O7
Molecular Weight
454.439
Canonical SMILES
COCCOc1cc2ncnc(NC3=CC(=O)C(N4CC(C)OC4=O)=CC3=O)c2cc1OC
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InChI
InChI=1S/C22H22N4O7/c1-12-10-26(22(29)33-12)16-9-17(27)15(7-18(16)28)25-21-13-6-19(31-3)20(32-5-4-30-2)8-14(13)23-11-24-21/h6-9,11-12H,4-5,10H2,1-3H3,(H,23,24,25)
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InChIKey
WJHGKFUOCDSBSI-UHFFFAOYSA-N
Physicochemical Property
logP
1.8358
Rotatable Bonds
8
Heavy Atom Count
33
Polar Areas
129.18
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
10
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 11683901
SID: 16788088
ChEMBL ID
CHEMBL3706839
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 > 1000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 7.3 nM
2 IC50 = 10.3 nM
3 IC50 > 1000 nM