General Information of the Compound
Compound ID
CP0662437
Compound Name
Trifluoro-acetate(S)-1-((1S,2S)-1-cyano-2-phenyl-cyclopropylcarbamoyl)-2-(2-fluoro-phenyl)-ethyl-ammonium
    Show/Hide
Structure
Formula
C21H19F4N3O3
Molecular Weight
437.393
Canonical SMILES
N#C[C@]1(NC(=O)[C@@H](N)Cc2ccccc2F)C[C@H]1c1ccccc1.O=C(O)C(F)(F)F
    Show/Hide
InChI
InChI=1S/C19H18FN3O.C2HF3O2/c20-16-9-5-4-8-14(16)10-17(22)18(24)23-19(12-21)11-15(19)13-6-2-1-3-7-13;3-2(4,5)1(6)7/h1-9,15,17H,10-11,22H2,(H,23,24);(H,6,7)/t15-,17-,19+;/m0./s1
    Show/Hide
InChIKey
ACLOSPXSOURJGD-UEXRLZNCSA-N
Physicochemical Property
logP
2.89488
Rotatable Bonds
5
Heavy Atom Count
31
Polar Areas
116.21
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 46905615
ChEMBL ID
CHEMBL1162477
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01629, Cathepsin G
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
Protein ID: PT00992, Neutrophil elastase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 1900 nM
   TI
   LI
   LO
   TS