General Information of the Compound
Compound ID
CP0661209
Compound Name
rac-trans-N-{4-[4-(2-Phenylcyclopropanecarbonyl)piperazine-1-sulfonyl]phenyl}acrylamide
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Structure
Formula
C23H25N3O4S
Molecular Weight
439.537
Canonical SMILES
C=CC(=O)Nc1ccc(S(=O)(=O)N2CCN(C(=O)[C@H]3C[C@@H]3c3ccccc3)CC2)cc1
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InChI
InChI=1S/C23H25N3O4S/c1-2-22(27)24-18-8-10-19(11-9-18)31(29,30)26-14-12-25(13-15-26)23(28)21-16-20(21)17-6-4-3-5-7-17/h2-11,20-21H,1,12-16H2,(H,24,27)/t20-,21+/m1/s1
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InChIKey
VKBTYOLWPAQPQN-RTWAWAEBSA-N
Physicochemical Property
logP
2.4477
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
86.79
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 56954302
SID: 135666516
ChEMBL ID
CHEMBL2367730
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01854, Protein-glutamine gamma-glutamyltransferase 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
IC50 = 1200 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 34 nM