General Information of the Compound
Compound ID
CP0579865
Compound Name
N-[4-cyano-3-(trifluoromethyl)phenyl]-3-[3-(1H-pyrrolo[2,3-b]pyridin-5-yl)phenyl]propanamide
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Structure
Formula
C24H17F3N4O
Molecular Weight
434.421
Canonical SMILES
FC(F)(F)c1cc(NC(=O)CCc2cccc(c2)-c2cnc3[nH]ccc3c2)ccc1C#N
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InChI
InChI=1S/C24H17F3N4O/c25-24(26,27)21-12-20(6-5-18(21)13-28)31-22(32)7-4-15-2-1-3-16(10-15)19-11-17-8-9-29-23(17)30-14-19/h1-3,5-6,8-12,14H,4,7H2,(H,29,30)(H,31,32)
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InChIKey
UPPDETQJTDKFRY-UHFFFAOYSA-N
Physicochemical Property
logP
5.69168
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
81.57
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168286848
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01975, Cyclin-dependent kinase 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000067 HCT 116 Homo sapiens (Human)  1
1
IC50 = 2000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 125.9 nM