General Information of the Compound
Compound ID
CP0579431
Compound Name
N-(1-azabicyclo[2.2.2]octan-3-yl)-5-chloro-7-[2-(2-fluoroethoxy)phenyl]-1-benzofuran-2-carboxamide
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Structure
Formula
C24H24ClFN2O3
Molecular Weight
442.918
Canonical SMILES
FCCOc1ccccc1-c1cc(Cl)cc2cc(oc12)C(=O)NC1CN2CCC1CC2
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InChI
InChI=1S/C24H24ClFN2O3/c25-17-11-16-12-22(24(29)27-20-14-28-8-5-15(20)6-9-28)31-23(16)19(13-17)18-3-1-2-4-21(18)30-10-7-26/h1-4,11-13,15,20H,5-10,14H2,(H,27,29)
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InChIKey
KBGOFGITDNESDT-UHFFFAOYSA-N
Physicochemical Property
logP
4.9255
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
54.71
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
4
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 162763855
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02611, Ceramide glucosyltransferase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000045 A-375 Homo sapiens (Human)  1
1
EC50 = 0.02 nM
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