General Information of the Compound
Compound ID
CP0578225
Compound Name
N-[3-(4-acetylpiperazin-1-yl)-5-fluorophenyl]-4-fluoro-7-methyl-1H-indole-2-carboxamide
    Show/Hide
Structure
Formula
C22H22F2N4O2
Molecular Weight
412.44
Canonical SMILES
CC(=O)N1CCN(CC1)c1cc(F)cc(NC(=O)c2cc3c(F)ccc(C)c3[nH]2)c1
    Show/Hide
InChI
InChI=1S/C22H22F2N4O2/c1-13-3-4-19(24)18-12-20(26-21(13)18)22(30)25-16-9-15(23)10-17(11-16)28-7-5-27(6-8-28)14(2)29/h3-4,9-12,26H,5-8H2,1-2H3,(H,25,30)
    Show/Hide
InChIKey
DTKJRMMWEXPPEW-UHFFFAOYSA-N
Physicochemical Property
logP
3.67532
Rotatable Bonds
3
Heavy Atom Count
30
Polar Areas
68.44
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
3
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 168281991
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02217, Histone-lysine N-methyltransferase SETD2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000068 A-549 Homo sapiens (Human)  1
1
IC50 = 41 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 12 nM