General Information of the Compound
Compound ID
CP0578073
Compound Name
2-[[(1R)-1-[4-[5-chloro-2-[2-[2-[2-[2-[2-[2-[2-[13-[4-(ethylamino)-4-oxobutanoyl]-3,4,5,13-tetrazatetracyclo[13.4.0.02,6.07,12]nonadeca-1(19),2(6),3,7,9,11,15,17-octaen-5-yl]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylcarbamoyl]phenyl]phenyl]ethyl]-(cyclopropylmethyl)amino]-5-cyclopropyl-N-cyclopropylsulfonyl-1,3-thiazole-4-carboxamide
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Structure
Formula
C64H78ClN9O12S2
Molecular Weight
1264.966
Canonical SMILES
CCNC(=O)CCC(=O)N1Cc2ccccc2-c2nnn(CCOCCOCCOCCOCCOCCOCCNC(=O)c3ccc(Cl)cc3-c3ccc(cc3)[C@@H](C)N(CC3CC3)c3nc(C(=O)NS(=O)(=O)C4CC4)c(s3)C3CC3)c2-c2ccccc12
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InChI
InChI=1S/C64H78ClN9O12S2/c1-3-66-56(75)24-25-57(76)73-42-48-8-4-5-9-51(48)58-60(53-10-6-7-11-55(53)73)74(71-69-58)27-29-82-31-33-84-35-37-86-39-38-85-36-34-83-32-30-81-28-26-67-62(77)52-23-20-49(65)40-54(52)46-16-14-45(15-17-46)43(2)72(41-44-12-13-44)64-68-59(61(87-64)47-18-19-47)63(78)70-88(79,80)50-21-22-50/h4-11,14-17,20,23,40,43-44,47,50H,3,12-13,18-19,21-22,24-39,41-42H2,1-2H3,(H,66,75)(H,67,77)(H,70,78)/t43-/m1/s1
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InChIKey
LRGZLGGNFMCMMO-VZUYHUTRSA-N
Physicochemical Property
logP
8.7585
Rotatable Bonds
36
Heavy Atom Count
88
Polar Areas
243.97
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
18
Complexity
88

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168294228
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03813, Chemerin-like receptor 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000681 CAL-1 [Human melanoma] Homo sapiens (Human)  1
1
IC50 = 9.1 nM
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