General Information of the Compound
Compound ID
CP0576832
Compound Name
N-[2-[[3-(3,5-dimethoxybenzoyl)-1H-pyrrolo[2,3-b]pyridin-6-yl]amino]-5-(1-methylpyrazol-4-yl)phenyl]prop-2-enamide
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Structure
Formula
C29H26N6O4
Molecular Weight
522.565
Canonical SMILES
COc1cc(OC)cc(c1)C(=O)c1c[nH]c2nc(Nc3ccc(cc3NC(=O)C=C)-c3cnn(C)c3)ccc12
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InChI
InChI=1S/C29H26N6O4/c1-5-27(36)33-25-12-17(19-14-31-35(2)16-19)6-8-24(25)32-26-9-7-22-23(15-30-29(22)34-26)28(37)18-10-20(38-3)13-21(11-18)39-4/h5-16H,1H2,2-4H3,(H,33,36)(H2,30,32,34)
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InChIKey
FKFWVUXFUKUSBI-UHFFFAOYSA-N
Physicochemical Property
logP
5.0797
Rotatable Bonds
9
Heavy Atom Count
39
Polar Areas
123.16
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
39

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168281452
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01343, Fibroblast growth factor receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000012 Sf21 Spodoptera frugiperda (Fall armyworm)  1
1
IC50 = 5.7 nM
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