General Information of the Compound
Compound ID
CP0574463
Compound Name
1-(4-bromophenyl)sulfonyl-3-[(4-methylpiperazin-1-yl)methyl]-5-(2,2,2-trifluoroethoxy)indole
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Structure
Formula
C22H23BrF3N3O3S
Molecular Weight
546.409
Canonical SMILES
CN1CCN(Cc2cn(c3ccc(OCC(F)(F)F)cc23)S(=O)(=O)c2ccc(Br)cc2)CC1
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InChI
InChI=1S/C22H23BrF3N3O3S/c1-27-8-10-28(11-9-27)13-16-14-29(33(30,31)19-5-2-17(23)3-6-19)21-7-4-18(12-20(16)21)32-15-22(24,25)26/h2-7,12,14H,8-11,13,15H2,1H3
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InChIKey
DFEVLZQWMZMXLN-UHFFFAOYSA-N
Physicochemical Property
logP
4.3293
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
54.78
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137644129
ChEMBL ID
CHEMBL4087429
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 96.3 nM
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