General Information of the Compound
Compound ID
CP0573823
Compound Name
(NE)-N-[6-[2-(4,4-difluoropiperidin-1-yl)ethoxy]-2-pyrrolo[1,2-c]pyrimidin-3-ylchromen-4-ylidene]hydroxylamine
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Structure
Formula
C23H22F2N4O3
Molecular Weight
440.45
Canonical SMILES
O\N=c1/cc(oc2ccc(OCCN3CCC(F)(F)CC3)cc12)-c1cc2cccn2cn1
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InChI
InChI=1S/C23H22F2N4O3/c24-23(25)5-8-28(9-6-23)10-11-31-17-3-4-21-18(13-17)19(27-30)14-22(32-21)20-12-16-2-1-7-29(16)15-26-20/h1-4,7,12-15,30H,5-6,8-11H2/b27-19+
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InChIKey
MYPZWCPHVXNILC-ZXVVBBHZSA-N
Physicochemical Property
logP
4.1473
Rotatable Bonds
5
Heavy Atom Count
32
Polar Areas
75.5
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
7
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137658747
ChEMBL ID
CHEMBL4098128
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02199, Metabotropic glutamate receptor 4
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
EC50 = 150 nM
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