General Information of the Compound
Compound ID
CP0570909
Compound Name
4-fluoro-3-[[6-methoxy-7-[3-(methylamino)propoxy]quinazolin-4-yl]amino]-2-methylphenol
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Structure
Formula
C20H23FN4O3
Molecular Weight
386.427
Canonical SMILES
CNCCCOc1cc2ncnc(Nc3c(C)c(O)ccc3F)c2cc1OC
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InChI
InChI=1S/C20H23FN4O3/c1-12-16(26)6-5-14(21)19(12)25-20-13-9-17(27-3)18(28-8-4-7-22-2)10-15(13)23-11-24-20/h5-6,9-11,22,26H,4,7-8H2,1-3H3,(H,23,24,25)
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InChIKey
BLFVZBOEPKVDQQ-UHFFFAOYSA-N
Physicochemical Property
logP
3.52342
Rotatable Bonds
8
Heavy Atom Count
28
Polar Areas
88.53
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
7
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 118112144
ChEMBL ID
CHEMBL3799756
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 > 10000 nM
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