General Information of the Compound
Compound ID
CP0570774
Compound Name
5-(6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-yloxy)-N-[5-(oxan-4-yl)-1,2-oxazol-3-yl]indole-1-carboxamide
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Structure
Formula
C23H22N6O4
Molecular Weight
446.467
Canonical SMILES
O=C(Nc1cc(on1)C1CCOCC1)n1ccc2cc(Oc3ncnc4CNCc34)ccc12
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InChI
InChI=1S/C23H22N6O4/c30-23(27-21-10-20(33-28-21)14-4-7-31-8-5-14)29-6-3-15-9-16(1-2-19(15)29)32-22-17-11-24-12-18(17)25-13-26-22/h1-3,6,9-10,13-14,24H,4-5,7-8,11-12H2,(H,27,28,30)
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InChIKey
SVGOQCWTCILNJV-UHFFFAOYSA-N
Physicochemical Property
logP
3.789
Rotatable Bonds
4
Heavy Atom Count
33
Polar Areas
116.33
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
9
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59394686
ChEMBL ID
CHEMBL4103383
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 12.8 nM
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