General Information of the Compound
Compound ID
CP0570772
Compound Name
5-[6-(methylaminomethyl)pyrimidin-4-yl]oxy-N-[5-(1-methylcyclopropyl)-1,2-oxazol-3-yl]indole-1-carboxamide
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Structure
Formula
C22H22N6O3
Molecular Weight
418.457
Canonical SMILES
CNCc1cc(Oc2ccc3n(ccc3c2)C(=O)Nc2cc(on2)C2(C)CC2)ncn1
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InChI
InChI=1S/C22H22N6O3/c1-22(6-7-22)18-11-19(27-31-18)26-21(29)28-8-5-14-9-16(3-4-17(14)28)30-20-10-15(12-23-2)24-13-25-20/h3-5,8-11,13,23H,6-7,12H2,1-2H3,(H,26,27,29)
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InChIKey
AQICPDDTSXPRAQ-UHFFFAOYSA-N
Physicochemical Property
logP
4.0627
Rotatable Bonds
6
Heavy Atom Count
31
Polar Areas
107.1
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
8
Complexity
31

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 59394220
ChEMBL ID
CHEMBL4097955
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00864, Vascular endothelial growth factor receptor 2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000077 Ba/F3 Mus musculus (Mouse)  1
1
IC50 = 9.4 nM
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