General Information of the Compound
Compound ID
CP0570594
Compound Name
N-[2-[(2S)-2-[2-[[2-(dimethylamino)-2-oxoethyl]amino]-2-oxoacetyl]pyrrolidin-1-yl]-2-oxoethyl]quinoline-4-carboxamide
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Formula
C22H25N5O5
Molecular Weight
439.472
Canonical SMILES
CN(C)C(=O)CNC(=O)C(=O)[C@@H]1CCCN1C(=O)CNC(=O)c1ccnc2ccccc12
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InChI
InChI=1S/C22H25N5O5/c1-26(2)18(28)12-25-22(32)20(30)17-8-5-11-27(17)19(29)13-24-21(31)15-9-10-23-16-7-4-3-6-14(15)16/h3-4,6-7,9-10,17H,5,8,11-13H2,1-2H3,(H,24,31)(H,25,32)/t17-/m0/s1
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InChIKey
CKLMZNAUXICCLY-KRWDZBQOSA-N
Physicochemical Property
logP
-0.2709
Rotatable Bonds
7
Heavy Atom Count
32
Polar Areas
128.78
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4868792
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01241, Prolyl endopeptidase FAP
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000090 Schneider 2 Drosophila melanogaster (Fruit fly)  1
1
IC50 = 5 nM
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