General Information of the Compound
Compound ID
CP0569987
Compound Name
4-[(6-pent-2-ynoxy-1-benzofuran-2-yl)-(1,2,4-triazol-1-yl)methyl]benzonitrile
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Structure
Formula
C23H18N4O2
Molecular Weight
382.423
Canonical SMILES
CCC#CCOc1ccc2cc(oc2c1)C(c1ccc(cc1)C#N)n1cncn1
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InChI
InChI=1S/C23H18N4O2/c1-2-3-4-11-28-20-10-9-19-12-22(29-21(19)13-20)23(27-16-25-15-26-27)18-7-5-17(14-24)6-8-18/h5-10,12-13,15-16,23H,2,11H2,1H3
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InChIKey
YPEJCSUYWBPALH-UHFFFAOYSA-N
Physicochemical Property
logP
4.32588
Rotatable Bonds
5
Heavy Atom Count
29
Polar Areas
76.87
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
6
Complexity
29

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 168274246
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01255, Aromatase
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000208 JEG-3 Homo sapiens (Human)  1
1
IC50 = 0.72 nM
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