General Information of the Compound
Compound ID
CP0569572
Compound Name
5-methoxy-3-[(4-methylpiperazin-1-yl)methyl]-1-[4-(trifluoromethoxy)phenyl]sulfonylindole
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Structure
Formula
C22H24F3N3O4S
Molecular Weight
483.512
Canonical SMILES
COc1ccc2n(cc(CN3CCN(C)CC3)c2c1)S(=O)(=O)c1ccc(OC(F)(F)F)cc1
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InChI
InChI=1S/C22H24F3N3O4S/c1-26-9-11-27(12-10-26)14-16-15-28(21-8-5-18(31-2)13-20(16)21)33(29,30)19-6-3-17(4-7-19)32-22(23,24)25/h3-8,13,15H,9-12,14H2,1-2H3
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InChIKey
FZUXYTUGTOXPCU-UHFFFAOYSA-N
Physicochemical Property
logP
3.5329
Rotatable Bonds
6
Heavy Atom Count
33
Polar Areas
64.01
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
7
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137648438
ChEMBL ID
CHEMBL4083959
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 37.8 nM
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