General Information of the Compound
Compound ID
CP0569053
Compound Name
2-[4-[4-[2-(4-methoxyphenyl)phenyl]piperazin-1-yl]butoxy]benzonitrile
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Formula
C28H31N3O2
Molecular Weight
441.575
Canonical SMILES
COc1ccc(cc1)-c1ccccc1N1CCN(CCCCOc2ccccc2C#N)CC1
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InChI
InChI=1S/C28H31N3O2/c1-32-25-14-12-23(13-15-25)26-9-3-4-10-27(26)31-19-17-30(18-20-31)16-6-7-21-33-28-11-5-2-8-24(28)22-29/h2-5,8-15H,6-7,16-21H2,1H3
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InChIKey
KEHDQKIGIJYMOP-UHFFFAOYSA-N
Physicochemical Property
logP
5.21508
Rotatable Bonds
9
Heavy Atom Count
33
Polar Areas
48.73
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4783043
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00819, 5-hydroxytryptamine receptor 1A
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 477 nM
   TI
   LI
   LO
   TS
Protein ID: PT00941, 5-hydroxytryptamine receptor 7
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 17.7 nM
   TI
   LI
   LO
   TS