General Information of the Compound
Compound ID
CP0567250
Compound Name
N-[3-[[6-[(4-fluorophenyl)methyl]-2-pyridin-2-yl-7,8-dihydro-5H-pyrido[4,3-d]pyrimidin-4-yl]amino]propyl]acetamide
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Structure
Formula
C24H27FN6O
Molecular Weight
434.519
Canonical SMILES
CC(=O)NCCCNc1nc(nc2CCN(Cc3ccc(F)cc3)Cc12)-c1ccccn1
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InChI
InChI=1S/C24H27FN6O/c1-17(32)26-12-4-13-28-23-20-16-31(15-18-6-8-19(25)9-7-18)14-10-21(20)29-24(30-23)22-5-2-3-11-27-22/h2-3,5-9,11H,4,10,12-16H2,1H3,(H,26,32)(H,28,29,30)
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InChIKey
SCSBXLIGNPSNOL-UHFFFAOYSA-N
Physicochemical Property
logP
3.1741
Rotatable Bonds
8
Heavy Atom Count
32
Polar Areas
83.04
Hydrogen Bond Donor Count
2
Hydrogen Bond Acceptor Count
6
Complexity
32

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 145950968
ChEMBL ID
CHEMBL4172497
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT02042, Cystic fibrosis transmembrane conductance regulator
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000535 CFBE41o- Homo sapiens (Human)  1
1
EC50 = 199.53 nM
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