General Information of the Compound
Compound ID
CP0565382
Compound Name
CHEMBL4862452
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Formula
C16H23N5O2
Molecular Weight
317.393
Canonical SMILES
NC(=O)c1cnc(N[C@H]2CC[C@H](O)CC2)nc1NC12CC(C1)C2
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InChI
InChI=1S/C16H23N5O2/c17-13(23)12-8-18-15(19-10-1-3-11(22)4-2-10)20-14(12)21-16-5-9(6-16)7-16/h8-11,22H,1-7H2,(H2,17,23)(H2,18,19,20,21)/t9?,10-,11-,16?
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InChIKey
IRUBRQUHIORGIW-QQRXUOGYSA-N
Physicochemical Property
logP
1.2553
Rotatable Bonds
5
Heavy Atom Count
23
Polar Areas
113.16
Hydrogen Bond Donor Count
4
Hydrogen Bond Acceptor Count
6
Complexity
23

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4862452
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06456, Mitogen-activated protein kinase 8
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000014 RAW 264.7 Mus musculus (Mouse)  1
1
IC50 = 170 nM
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