General Information of the Compound
Compound ID
CP0565057
Compound Name
3-[5-amino-6-(1,3-dimethylpyrazol-4-yl)pyrazin-2-yl]-N-(2-hydroxy-2-methylpropyl)-4-methylbenzenesulfonamide
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Structure
Formula
C20H26N6O3S
Molecular Weight
430.534
Canonical SMILES
Cc1nn(C)cc1-c1nc(cnc1N)-c1cc(ccc1C)S(=O)(=O)NCC(C)(C)O
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InChI
InChI=1S/C20H26N6O3S/c1-12-6-7-14(30(28,29)23-11-20(3,4)27)8-15(12)17-9-22-19(21)18(24-17)16-10-26(5)25-13(16)2/h6-10,23,27H,11H2,1-5H3,(H2,21,22)
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InChIKey
BCKQIDIXDOCRCK-UHFFFAOYSA-N
Physicochemical Property
logP
1.79234
Rotatable Bonds
6
Heavy Atom Count
30
Polar Areas
136.02
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
8
Complexity
30

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 126577433
ChEMBL ID
CHEMBL4878811
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01029, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 61 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 28 nM