General Information of the Compound
Compound ID
CP0564523
Compound Name
4-(3-ethenyl-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-propan-2-ylpyrido[2,3-d]pyrimidin-2-one
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Structure
Formula
C24H22F2N6O2
Molecular Weight
464.476
Canonical SMILES
CC(C)n1c2nc(c(F)cc2c(nc1=O)N1CCn2c(C1)cnc2C=C)-c1c(O)cccc1F
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InChI
InChI=1S/C24H22F2N6O2/c1-4-19-27-11-14-12-30(8-9-31(14)19)22-15-10-17(26)21(20-16(25)6-5-7-18(20)33)28-23(15)32(13(2)3)24(34)29-22/h4-7,10-11,13,33H,1,8-9,12H2,2-3H3
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InChIKey
WBMLTPYQIMMAFA-UHFFFAOYSA-N
Physicochemical Property
logP
3.8829
Rotatable Bonds
4
Heavy Atom Count
34
Polar Areas
89.07
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
8
Complexity
34

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 164054598
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03462, GTPase KRas
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000207 MIA PaCa-2 Homo sapiens (Human)  1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 100 nM