General Information of the Compound
Compound ID
CP0564522
Compound Name
4-(3-ethenyl-6,8-dihydro-5H-imidazo[1,5-a]pyrazin-7-yl)-6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-(4-methyl-2-propan-2-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-2-one
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Structure
Formula
C30H27F2N7O2
Molecular Weight
555.589
Canonical SMILES
CC(C)c1nccc(C)c1-n1c2nc(c(F)cc2c(nc1=O)N1CCn2c(C1)cnc2C=C)-c1c(O)cccc1F
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InChI
InChI=1S/C30H27F2N7O2/c1-5-23-34-14-18-15-37(11-12-38(18)23)28-19-13-21(32)26(24-20(31)7-6-8-22(24)40)35-29(19)39(30(41)36-28)27-17(4)9-10-33-25(27)16(2)3/h5-10,13-14,16,40H,1,11-12,15H2,2-4H3
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InChIKey
NANFHWVKNWZUGL-UHFFFAOYSA-N
Physicochemical Property
logP
5.11802
Rotatable Bonds
5
Heavy Atom Count
41
Polar Areas
101.96
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
9
Complexity
41

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 163795638
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT03462, GTPase KRas
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000207 MIA PaCa-2 Homo sapiens (Human)  1
1
IC50 = 5000 nM
   TI
   LI
   LO
   TS
Biochemical Assays
1 IC50 = 100 nM