General Information of the Compound
Compound ID
CP0562792
Compound Name
(2S)-24-(azetidin-1-yl)-11-fluoro-18,21-dimethyl-15-oxa-7,18,21,25,27,28-hexazapentacyclo[24.2.1.02,7.09,14.022,27]nonacosa-1(28),9(14),10,12,22,24,26(29)-heptaene-8,17-dione
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Structure
Formula
C27H32FN7O3
Molecular Weight
521.597
Canonical SMILES
CN1CCN(C)C(=O)COc2ccc(F)cc2C(=O)N2CCCC[C@H]2c2cc3nc(cc1n3n2)N1CCC1
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InChI
InChI=1S/C27H32FN7O3/c1-31-12-13-32(2)26(36)17-38-22-8-7-18(28)14-19(22)27(37)34-11-4-3-6-21(34)20-15-24-29-23(33-9-5-10-33)16-25(31)35(24)30-20/h7-8,14-16,21H,3-6,9-13,17H2,1-2H3/t21-/m0/s1
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InChIKey
AOCKQJYVQIFDFU-NRFANRHFSA-N
Physicochemical Property
logP
2.7329
Rotatable Bonds
1
Heavy Atom Count
38
Polar Areas
86.52
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
8
Complexity
38

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 154969863
ChEMBL ID
CHEMBL4752460
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06676, Fusion glycoprotein F0
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000063 Hep-G2 Homo sapiens (Human)  1
1
EC50 = 1.4 nM
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