General Information of the Compound
Compound ID
CP0561853
Compound Name
methyl (2S)-3-methyl-2-[[(2S,3S)-3-methyl-2-[[2-oxo-2-(2-phenyl-1H-indol-3-yl)acetyl]amino]pentanoyl]amino]butanoate
    Show/Hide
Structure
Formula
C28H33N3O5
Molecular Weight
491.588
Canonical SMILES
CC[C@H](C)[C@H](NC(=O)C(=O)c1c([nH]c2ccccc12)-c1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)OC
    Show/Hide
InChI
InChI=1S/C28H33N3O5/c1-6-17(4)23(26(33)30-22(16(2)3)28(35)36-5)31-27(34)25(32)21-19-14-10-11-15-20(19)29-24(21)18-12-8-7-9-13-18/h7-17,22-23,29H,6H2,1-5H3,(H,30,33)(H,31,34)/t17-,22-,23-/m0/s1
    Show/Hide
InChIKey
SWTHVLJASKSMJY-RTFZILSDSA-N
Physicochemical Property
logP
3.8623
Rotatable Bonds
10
Heavy Atom Count
36
Polar Areas
117.36
Hydrogen Bond Donor Count
3
Hydrogen Bond Acceptor Count
5
Complexity
36

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 127051542
ChEMBL ID
CHEMBL3818934
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01771, E3 ubiquitin-protein ligase Mdm2
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000102 U-87MG ATCC Homo sapiens (Human)  1
1
IC50 = 77.7 nM
   TI
   LI
   LO
   TS