General Information of the Compound
Compound ID
CP0558924
Compound Name
5-methyl-N-[(3S)-5-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-1,2-oxazole-3-carboxamide
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Structure
Formula
C15H15N3O4
Molecular Weight
301.302
Canonical SMILES
CN1c2ccccc2OC[C@H](NC(=O)c2cc(C)on2)C1=O
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InChI
InChI=1S/C15H15N3O4/c1-9-7-10(17-22-9)14(19)16-11-8-21-13-6-4-3-5-12(13)18(2)15(11)20/h3-7,11H,8H2,1-2H3,(H,16,19)/t11-/m0/s1
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InChIKey
WFVAIXPNICATFZ-NSHDSACASA-N
Physicochemical Property
logP
1.13682
Rotatable Bonds
2
Heavy Atom Count
22
Polar Areas
84.67
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
22

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 137634539
ChEMBL ID
CHEMBL4061414
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00954, Receptor-interacting serine/threonine-protein kinase 1
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000100 U-937 Homo sapiens (Human)  1
1
IC50 = 12600 nM
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