General Information of the Compound
Compound ID
CP0558320
Compound Name
3-[(3,5-difluorophenoxy)methyl]-N,N-diethyl-1-methyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridine-5-sulfonamide
    Show/Hide
Structure
Formula
C18H24F2N4O3S
Molecular Weight
414.478
Canonical SMILES
CCN(CC)S(=O)(=O)N1CCc2c(C1)c(COc1cc(F)cc(F)c1)nn2C
    Show/Hide
InChI
InChI=1S/C18H24F2N4O3S/c1-4-23(5-2)28(25,26)24-7-6-18-16(11-24)17(21-22(18)3)12-27-15-9-13(19)8-14(20)10-15/h8-10H,4-7,11-12H2,1-3H3
    Show/Hide
InChIKey
ULKJRXZVUZQXCZ-UHFFFAOYSA-N
Physicochemical Property
logP
2.222
Rotatable Bonds
7
Heavy Atom Count
28
Polar Areas
67.67
Hydrogen Bond Donor Count
0
Hydrogen Bond Acceptor Count
5
Complexity
28

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

    Show/Hide
Click to Show/Hide the External Link(s) of This Compound
PubChem ID
CID: 155517568
ChEMBL ID
CHEMBL4444793
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT06851, Pendrin
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000259 FRT Rattus norvegicus (Rat)  1
1
IC50 > 10000 nM
   TI
   LI
   LO
   TS