General Information of the Compound
Compound ID
CP0555292
Compound Name
(3S,4S)-3-Phenyl-4-(4-phenyl-piperidin-1-ylmethyl)-pyrrolidine-1-carboxylic acid phenylamide
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Structure
Formula
C29H33N3O
Molecular Weight
439.603
Canonical SMILES
O=C(Nc1ccccc1)N1C[C@H](CN2CCC(CC2)c2ccccc2)[C@H](C1)c1ccccc1
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InChI
InChI=1S/C29H33N3O/c33-29(30-27-14-8-3-9-15-27)32-21-26(28(22-32)25-12-6-2-7-13-25)20-31-18-16-24(17-19-31)23-10-4-1-5-11-23/h1-15,24,26,28H,16-22H2,(H,30,33)/t26-,28+/m0/s1
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InChIKey
COMVHBCGMOXRMN-XTEPFMGCSA-N
Physicochemical Property
logP
5.8137
Rotatable Bonds
5
Heavy Atom Count
33
Polar Areas
35.58
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
2
Complexity
33

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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PubChem ID
CID: 489805
ChEMBL ID
CHEMBL93644
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT00903, C-C chemokine receptor type 5
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000011 CHO Cricetulus griseus (Chinese hamster)  1
1
IC50 = 610 nM
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