General Information of the Compound
Compound ID
CP0554895
Compound Name
4-[5-[4-[1-[(3-chlorophenyl)methyl]indol-4-yl]piperazin-1-yl]pentoxy]-N-prop-2-ynyl-2,3-dihydro-1H-inden-1-amine
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Formula
C36H41ClN4O
Molecular Weight
581.204
Canonical SMILES
Clc1cccc(Cn2ccc3c(cccc23)N2CCN(CCCCCOc3cccc4C(CCc34)NCC#C)CC2)c1
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InChI
InChI=1S/C36H41ClN4O/c1-2-18-38-33-16-15-31-30(33)11-7-14-36(31)42-25-5-3-4-19-39-21-23-40(24-22-39)34-12-8-13-35-32(34)17-20-41(35)27-28-9-6-10-29(37)26-28/h1,6-14,17,20,26,33,38H,3-5,15-16,18-19,21-25,27H2
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InChIKey
PGKATOLEFVWLSG-UHFFFAOYSA-N
Physicochemical Property
logP
6.9244
Rotatable Bonds
12
Heavy Atom Count
42
Polar Areas
32.67
Hydrogen Bond Donor Count
1
Hydrogen Bond Acceptor Count
5
Complexity
42

"RO5" indicates the cutoff set by lipinski's rule of five:

(1) Molecular weight less than 500 Dalton;

(2) xlogp less than 5;

(3) No more than 5 hbonddonor (Hydrogen Bond Donor Count);

(4) No more than 10 hbondacc (Hydrogen Bond Acceptor Count);

(5) No more than 10 rotbonds (Rotatable Bond Count).

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ChEMBL ID
CHEMBL4754407
Map of Molecular Bioactivity Related to the Compound
Map of Molecular Bioactivity Related to the Compound

Compound
Cell Line
Protein

Bioactivity Value:

<= 0.1 μM
> 0.1 μM and <= 10 μM
> 10 μM
Imprecise Activity
Table of Molecular Bioactivities Related to the Compound
Protein ID: PT01354, 5-hydroxytryptamine receptor 6
Cell-based Assay
Cell Line ID Cell Line Name Cell Line Organism
CL000006 HEK293 Homo sapiens (Human)  1
1
Ki = 223 nM
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